We are a signal transduction, systems biology and proteomics lab located in the Lunenfeld-Tanenbaum Research Institute in Toronto.

Reversible protein phosphorylation is mediated by a network of protein kinases and phosphatases that regulate the response of cells to environmental stimuli. Importantly, misregulation of this process has been implicated in numerous diseases, including cancer and diabetes. We are particularly interested in understanding how phosphatases respond to different environmental cues and how they recognize their substrates. We are applying quantitative proteomics approaches, as well as an array of biochemical and cell biology techniques, to shed light on this important enzyme family. This being said, we also have other fun projects, which you can see under the Research tab.

We also develop technologies and software tools for proteomics, primarily for the analysis of protein-protein interactions. These are listed under the Resources tab. Have a look at our experimental protocols and available cloning vectors. Please also see our dedicated website for the distribution of ProHits, a Laboratory Information Management System for AP-MS experiments. Explore the Contaminant Repository for Affinity Purification (or CRAPome), a resource to help biologists making sense of their interaction data, and navigate our own Interaction Repository.

Recent funding from Genome Canada enabled the creation at the Lunenfeld-Tanenbaum of the Network Biology Collaborative Centre (NBCC) who is now accepting samples in both the SMART screening and proteomics facilities.